That looks to me like the location of Venice at the top of the Adriatic. Perhaps some sort of trading game?

Questron?

Questron II?

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Annals of Rome?

Oooo another game by this game’s publisher has now been mentioned. As for the place, not quite Venice, but near the clue below:
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Railroad tycoon

Nope. Let me add just a bit more to the frame:
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Pong?

A very off-course Oregon Trail?

LOL. I will not fail to have my game guessed for the third straight time!
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Railroad Tyccoon for the C64?

Wasteland?

road war?

Close enough! Yay! “Roadwar 2000” by SSI (who also did the aforementioned Questron II). I loved this game, it was so cool cruising about the U.S. of A. with my crew, doing battle car v. car. And that box art by the incredible Louis Saekow.

I had never heard about the game, but checked them out a bit when they were mentionned, incidently, on the Game Cover thread.
Only mentionned it because there was a car, but it turns out I was thinking Road War Europa :O

Anyway:

Final Fantasy… 13?

Eternal Sonata?

Looks like the “romance” scene from Final Fantasy X, but the screen should be wider. Maybe it’s a mobile or 3DS game? Hmmm…