rho21
1925
That looks to me like the location of Venice at the top of the Adriatic. Perhaps some sort of trading game?
Oooo another game by this game’s publisher has now been mentioned. As for the place, not quite Venice, but near the clue below:

Nope. Let me add just a bit more to the frame:

A very off-course Oregon Trail?
LOL. I will not fail to have my game guessed for the third straight time!

Railroad Tyccoon for the C64?
Close enough! Yay! “Roadwar 2000” by SSI (who also did the aforementioned Questron II). I loved this game, it was so cool cruising about the U.S. of A. with my crew, doing battle car v. car. And that box art by the incredible Louis Saekow.
I had never heard about the game, but checked them out a bit when they were mentionned, incidently, on the Game Cover thread.
Only mentionned it because there was a car, but it turns out I was thinking Road War Europa :O
Anyway:
Looks like the “romance” scene from Final Fantasy X, but the screen should be wider. Maybe it’s a mobile or 3DS game? Hmmm…