I like experimenting. I got this wicked weapon for my laser guy and things just melt and it’s not even a blue or legendary. I didn’t use laser last go around - stuck to cryo, shotguns, snipers and plasma. So this time I’m rockin shotty, machine gun, sniper & laser. We’ll see how far this can go.
From my last playthrough - Cryo and Plasma are a wicked combo. One freezes everything and the other just puts on the damage. I like shotty’s because of the push-back. Those 3 together can pretty much hold and contain any type of blob and you have either machine guns or snipers for cleaning up leaks.