I just read the blog and I’ll summarize briefly.

Basically, the skill selection interface is going away and now you select your skills using the skill bar interface (the one that runs along the bottom of the screen), near as I can tell. This does sound like a better fit - it always felt weird to have to first pick a skill to have active and then assign it to a button.
The second skill change is they have defined what catagory (primary, secondary, utility) that a skill falls in and by default that defines where those skills are mapped - primary to left mouse, secondary to right, etc. This is OPTIONAL though - if you feel like you know better or have a build in mind that doesn’t fit this mold, you can chose an Elective Mode which will overwrite the defaults and let you assign whatever you want to whatever. It’ assumed most people will leave it at default until they play for most of the Normal difficulty and at some point want the flexibility Elective Mode will provide as they come up with new builds to try out.
The change to Runestones is there are no more runestones! Instead they are called Skill Runes and they unlock as you level - starting at level 6, so we’ll have some runes to play with in the beta now. There would have been over 3,000 itemized runes and it was becoming a massive headache to manage them in your inventory and trying to juggle runes to equip, runes to store, runes to get rid of, etc.
Now they unlock as you level up and they are not ranked any longer - instead they are just a big, powerful adjustment/mod to a skill as soon as you unlock a rune. You get to pick what rune type to unlock when you hit a level that allows that (such as level 6) and what skill to stick to that rune.

Looks like the maintenance was exctended until about 10pm CST so it’s going to be awhile before I can try this stuff myself, but I definately approve of the new skill interface, and if you get to build your skills by picking runes as you level, I’m DEFINATELY on board for that change, as well.
Also, having to juggle all those runes sounded like a fiasco - we already have gems to have to manage, anyway.
What do you guys think?