I recently picked up the Harmony Home Ultimate because our Pronto was consistently malfunctioning. It's basically the hub system with a fancy RF remote.
My experience is that the IR mini blasters help. In my setup, the hub is in the AV cabinet, and not directly facing anything. This works because the hub is very bright, bright enough that reflected IR light reaches the AV components. It can be brighter than an IR remote because it's AC powered, not battery powered.
Even so, the hub wasn't reaching the 360 and XBone in a secondary cabinet. I threaded a mini IR blaster over there and everything worked. The IR blaster is again not facing the room, not the equipment, and working on reflected light. Yet makes a difference.