I finally saw it this week in NYC, with tickets we bought 9 months ago.
So the original cast is long gone. If you've listened to the soundtrack a lot then it will feel a bit off, but I was still amazed.
We got the understudy for Burr during our performance and frankly I didn't think much of how he did, which is a problem given that he is essentially the main character. But the rest of the current cast was fantastic.