Yup! My mother and father in law got covid a few months ago. They wound up on molnupiravir instead because they couldn’t get off their meds that had interactions. The thing with paxlovid is that it’s actually 2 drugs. One drug is the antiviral, and the other drug (ritonavir) boosts its efficacy, but also has lot of interactions.
Key drug interactions: You should not take ritonavir with any of the following drugs: alfuzosin, amiodarone, astemizole, bepridil, avanafil, chlorazepate, cisapride, colchicine, diazepam, dihydroergotamine, dronedarone, elbasvir/grazoprevir, ergonovine, ergotamine, estazolam, flecanaide, flurazepam, fusidic acid, lovastatin, lurasidone, ombitasvir/paritaprevir/ritonavir, methylergonovine, midazolam taken orally, pethidine, pimozide, piroxicam, propafenone, quetiapine, ranolazine, sildenafil (for hypertension), simvastatin, St John’s wort, terfenadine, triazolam, vardenafil.
Ritonavir interacts with many other medications and can change blood levels of one or both drugs. Consult your doctor or HIV pharmacist before taking any other drugs with ritonavir or a ritonavir-boosted drug. This includes: calcium channel blockers, drugs for heart conditions, anticoagulants, asthma and allergy drugs, proton pump inhibitors and H2 receptors, indigestion remedies, anti-fungal treatments, anticonvulsants, anti-TB drugs rifabutin and rifapentine, immunosuppressants, some chemotherapy drugs, steroid-containing inhalers, nasal sprays, eye drops, creams, as well as medicines bought from a high-street chemist, herbal preparations and recreational drugs.