Well, only in so far as strategy. Going Dex and using a STR weapon or vice versa. There are some DS bosses where I really wonder how a Spell user could last long enough or hit hard enough, although those are mainly DLC bosses.
This play thru I am toying with the idea of switching to a spell caster towards the DLCs just to see how it works. I have solo’d DS1 and DS2 base games that way, but the flask switching seemed to me a recipe for disaster in DS3.