All I can find on reddit is disagreement up to the point where someone references this tweet from one of the designers:
At which point, okay, there’s a Bungie dev saying mods don’t affect drops.
But man, I really think it does, at least up to a point. A lot of the “no it doesn’t” anecdotes are from people at or above 300, where I suspect the calculations may again be different—as they seem to be at the 265 point.
I’m not going to argue the point, but my own experience doesn’t seem to back this up, so I remain personally unconvinced for now.
In any case, the strategies for gearing up are unchanged for all but the most extreme min/maxing of scenarios, so the rest of the discussion in this thread should hold up.