Advanced Edition adds some new stuff, some new events. I think it’s worth playing once you’ve already seen most of the base game content.
In particular it adds the cloning bay (as a medbay replacement). As you might expect, this will replace any dead crew members (at a small cost to their XP). This makes the alien spiders event well worth doing as the downside is so much lower.
There are a few blue options for that event. Spoiled in case people don’t want to know.
Blue options appear if you have a boarding drone, anti-personnel drone or Bio beam equipped. Not all the options are equivalent in terms of rewards, but they are all positive.