Going back to my Purifier (Inquisitor + Demolitionist), I’ve had really good luck just putting a couple of points into the Rune of (unknown - Fire) and Rune of (unknown- Cold).
Both of those Runes have allowed me to kill the occasional boss enemy that’s really far above my level. So I’ve died very rarely so far. I know most online advice I can find for a Purifier is to focus solely on my gun abilities, but gosh, just two points into those Runes, and their follow up skills is netting me so much area of effect damage in addition to my guns, that I’m tempted to ignore internet advice and just keep going in this direction. Maybe put a few points more into gun abilities, but also cultivate the two fire and ice Runes as well for being my damage dealers. Of course, eventually I have contend with the fact that one-handed pistols just don’t have much of a damage base. So all these abilities that are based on main hand damage and off hand damage are eventually going to all suck maybe against big bosses down the road.
I don’t know. We shall see. Maybe I’ll get lucky and find badass single handed pistols for each hand. Certainly all the blue pistols I’ve found in the game are nothing special in terms of damage compared to swords. But maybe the secret there is just that I’m supposed to concentrate on finding attack speed bonuses and get my dps up via that route. If I can shoot really really fast, then I don’t need my pistols to do as much damage as swords.