Maybe I don't follow MOBAs closely enough, but I'm surprised some designer hasn't already filled a lane with zombies and just called it a day..
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There are actually a number of ground breaking MOBAs that have come out in the past few years. Some have 3 or 4 teams, some let you invest in control points around the map to build outposts and grow your entire team's economy, and some let you invest in different types of troop waves and troop upgrades for your lane. Then again, these MOBAs are all on the Starcraft Arcade, and that's only a 2 star game. ;)