Yeah, it’s very easy to set up.
Each scenario has an Agenda Deck and an Act deck that typically consist of 3-6 cards. You lay them out and the card art makes it look like a book. You the investigators you control (if you’re playing solo) try to advance the Act deck. The game is trying to advance the Agenda deck. Pretty basic, but effective.
Your first scenario in a campaign can be a bit of a setup, as you build your investigator decks – especially if you’re playing two investigators as a solo game. For the first playthrough of the scenario in the box, go ahead and take the recommended starter decks they give you. They’re not perfect decks, but they work OK…and as a bonus, help to give you ideas about how you’d build BETTER decks the next time.
From there, the scenario setup is basically pulling cards. Having a good way to keep the various cards sorted when you store them is essential to making this easy. Basically you pull out certain cards to build a mythos deck (which is how the game fights back at you each turn) that’s unique to each scenario. You also pull a handful of location cards to lay out on the board. Some get put out immediately, some have to be revealed.
The last part of setup is throwing some chaos tokens into a bag, depending on how difficult you want your playthrough to be.
I’ve got a pretty good system for organizing my cards, and can get a game to set up and ready for turn one in 10 minutes or so, if I’ve already got my investigator decks built from a previous scenario.
Finally, there are a bunch of good learn-to-play videos online.
Here’s the official Fantasy Flight tutorial, which doesn’t cover everything, but is well done and will get you close:
And here’s the video for the very first scenario in the core box I linked up-thread. It’s a really basic, tutorial scenario that holds your hand a lot, but even so, that first time you play it can feel like “OK, so…whatnow?” I love this video because the players are learning the game with one experienced player who absolutely has the rules down cold (I LOVE it when a video playthrough of a board game has no rules flubs.) It’s just a terrific way to grok how the game works, and while it’s obviously spoilery…it’s the first scenario of three. Things get a LOT more involved in the next two!