When you think about it, game as an art-form has to be the most difficult medium there is. With books, movies, music, paintings, musicals - the target audience doesn’t get to take hold of them, kick their tires, and drive them around. The user is the end platform, receiving the artist’s directed energy. To look at gaming however, each interactive facet becomes it’s own little parable opening up the title to more intense scrutiny and more open interpretation. More chances for the artists original intend to be lost in the crowd.
On top of having to satisfy so many fields, you also have technical glitches and performance issues which in and of itself can hurt how the game comes across, potentially losing its artistic impact. This is why I think System Shock 2 is one of gaming’s best titles ever made. It made the best of each medium and had an emotional impact that was hard to shake.