I noticed some quests are time sensitive. Like the town guard beat me to the punch finding something. Doh.
Also in one of the early towns you go to, the Priest you meet there gives you two quests, but progressing in one may cause the other to fail as they both take place and take up most of the night. I had to reload to figure out the order of operations in order to complete both. (took 2 separate nights)
Also not a fan of the save system. I’ve already lost 20 minutes here, 15 minutes there, repeating the same segments over and over again, including mundane stuff like looting containers. I don’t got time for that. Also something I already had enough of in the prologue. No thanks. I grabbed the unlimited save mod. This makes alchemy much more optional rather than a defacto required activity to brew schnapps, which I think is fine. (the game really wants you to level up all the skills)