It will run fine with Defender. I’ve got it on 3 machines using Defender.
MBAM was designed to work in conjunction with AV software.
And with 3.0, Malwarebytes is actually touting MBAM as an antivirus replacement, but you can still run AV software. If you want to, go ahead. More layers of security is better, so long as they don’t nullify each other. But I plan on sticking with Defender and MBAM 3.0, and not running flash and java.
With the launch of Malwarebytes 3.0, we are confident that you can finally replace your traditional antivirus, thanks to our innovative and layered approach to preventing malware infections using a healthy combination of proactive and signature-less technologies. While signatures are still effective against threats like potentially unwanted programs, large portion of our malware detection events already come from our signature-less technologies like our Anti-Exploit and Anti-Ransomware; that trend will only continue to grow. For many of you, this is something you already know, since over 50% of our customers already run Malwarebytes as their sole security software, without any third-party antivirus. But rest assured, we continue to support compatibility if you choose to use a third-party antivirus or other security software alongside Malwarebytes 3.0.[/quote]