It’s not any sort of real time click-fest if that’s what you’re worried about. You’re not clicking to directly control your guys. You are clicking to draw plans and set priorities, etc. You can pause at will.
Generally when I play there a long period where I’m paused while thinking about systems and drawing the orders to mine, build, etc. to create them. Then when things look right I un-pause to watch my guys do their thing. Then either in real time or paused I maybe tweak priorities to make sure things are getting done properly. While my guys are working I’m flipping through overlays to make sure everything is running well, vents are venting and pipes are piping and all that. Then as the current project is getting completed I starting thinking about and drawing up the next one.