Random thought thread!


#8573

How do they come up with drug names? I don’t mean the name we all see. The actual drug nomenclature. Some seem reasonable. Others are letter salad. Any Ideas?

adalimumab
tofacitinib
leflunomide


#8574

When a drug is first discovered, it is given a chemical name, which describes the atomic or molecular structure of the drug. The chemical name is thus usually too complex and cumbersome for general use.


#8575

Two of the drugs you listed are actually biologic antibodies while the third is a small molecule chemical. Both antibodies and small molecules have their separate naming conventions based on their origin or structure. My understanding is that, unlike newly discovered animals which the discover(s) have a say in the new scientific name, antibodies and drugs nomenclatures are pretty defined.

For example:


#8576

I had issues today.


#8577

Thanks for your replies. Very interesting.


#8578

I have been in the room for some hilariously painful discussions over what drug INN should be requested. My perennial suggestions of flopsiwopsimab and fuzziwuzzimab always go unheeded. But to be fair, the FDA and its counterparts reject names for amazing reasons, like “it sort of rhymes with this other company’s drug’s name and could be taken as a claim to have an effect with this other unrelated disease.”


#8579

This is gonna bother me if I don’t ask. Ok so this haircut looks frumpy now. Did it look frumpy back THEN too???


#8580

Oh yeah, a glammed-up Lucille Ball, totally the definition of frumpy.


#8581

No, it was quite stylish. And I don’t think it looks frumpy. Due to the age of the few women who still style their hair like that (excepting vintage enthusiasts), those women may look frumpy, but I don’t think it’s the hairstyle itself.

And just because I have it handy:


#8582

well you know, when I google lucille ball that was the first pic. But when I picture her in my mind’s eye, what pops up is her in rollers.


#8583


#8584

image


#8585

Wait so the TV was in black and white, but the magazine covers were in color?


#8586

Even in the early 1930s color printing was not common. By the time that I Love Lucy was televised it was much more common but not ubiquitous.


#8587

Lots of frumpy styles in the 40s and 50s. Not sure what the vintage folks like about them TBH. The 20s and 30s (or even before that) were much nicer.


#8588

Even in the 1960’s, when color printing had become more common, it still wasn’t quite universal. Sad sack Cleveland Browns fan that I am, I saved the issue of Sports Illustrated from when they won their last championship: 1964. The cover photo and all the photos from the game are in black and white. Inside was a long spread from the publisher explaining that they assigned their cameras with color film to the team they expected to win and their black and white cameras to the other team. The Browns were big underdogs to the Colts, so they wound up having to use all the black and white photos. The publisher’s spread also showed a number of color covers that had been worked up and never used because of upsets, including one of Sonny Liston who was supposed to beat that loud-mouth youngster, Cassius Clay.


#8589

It’s about the lifestyle. The hair is largely just part of the package.


#8590

Thanks to a text message from a generous stranger I have received 12 bitcoins! Lucky me.

Need I add a /s?


#8591

Yesterday my kids and I went out to have some fun in the snow, and they started piling up a bunch of snow to make what I thought was going to be a snowman. But it turned out to be a mound with a hole that my son kept urging me to stick my arm in:

And in the back of my mind I’m thinking that my kids had created the stump monster from Flash Gordon and they were testing me.

image


#8592

I must not fear. Fear is the mind-killer. Fear is the little-death that brings total obliteration. I will face my fear. I will permit it to pass over me and through me. And when it has gone past I will turn the inner eye to see its path. Where the fear has gone there will be nothing. Only I will remain