There’s a capacity to have specific missions and cities, but the heart of the game is to be a procedurally generated detective game. So every time you play your investigation will be unique to you, so you can’t really spoil much other than the manner in which things are generated.
Or, to put it another way, it’s like saying you could spoil Dwarf Fortress by playing the original version Vs the latest.
I don’t know if a mod will chop out the old conversation and put it in this thread, but incase they don’t future readers should know it started here