Yeah, when I’ve faced them it involves some attrition and doing everything possible to not get caught in front of them. Most ship will just die if they get hit. The Terran ship is the only one, and maybe my Scryve battlecruiser but I wouldn’t want to waste it on that fight, that can survive and that is only if it quickly gets out of the firing line. Phamyst have been somewhat annoying as well, since they have an ability that lets them regen. So I end up beating them, but they wear down the crews of my ships, and there seem to be so many of them that I ended up with 4 or 5 engagements trying to get to the homeworld once in system.
I finally got my toxic defenses to a level where I can survive on some really nasty planets, which has helped with raising money to buy improvements. I haven’t really received that much money from missions outside of 2 instances I think.