The Elder Scrolls Online

I loved this mod when I played. Maybe not good for your first few hours. But after that it really allows you to focus on the excellent world building to guide you along - and not annoying UI pop-ups. They did a good job making attacks, mobs, quests, etc all appear distinct in the game.

http://www.esoui.com/downloads/info48-WykkydFullImmersion.html