I hear that binding fire to your mousewheel is a lot of fun with certain weapons…
I would enable “toggle sprint” in options, so you tap the key once when you load into an area and then ignore it the next load-in. I believe there’s also options to make crouch and aiming toggles if those would help.
I have a macro keyboard, so I have (for instance) a single keypress for bullet jump/slide. You can do the same thing with AutoHotKey.