I am using the Easywine app to tie .exes to Wine from the Finder. DOSBox is nice enough to allow such a simple usage.
If you are familiar with DOSBox and don’t need a front end to configure it, running it through Wine works beautifully: I double click the build customized for EF2000 in the Finder and it launches like any app would. It recognizes my joystick without any fuss.
You have lots of options to run Wine on the Mac (custom wrappers you can build, various massive launcher-gui thingies…), but since DOSBox works right out of the… box that, I just use that simple method for it.
On the Mac side, you have Boxer, which is a now defunct but still very sexy port of DOSBox with a lovely front end, screen filters and MT-32 emulation, and ways to access game’s documentation directly from it. Sadly, it’s got a couple of issues: you have to compile it yourself to get a working build on a modern OS X, it is slow (all Mac DOSBox builds really are in my experience, compared to running one in Wine), it doesn’t have the input mapping function of DOSbox (which is very much needed, oftentimes) and it’s got that fancy effect when you use a throttle that will freeze the DOS emulation while you are playing with it!
As for EF2000, as Brian said, nope :( If you find a copy, you will also have to install it, which is a major pain in the ass on modern Windows from what I understand — in Wine it is surprisingly easy.
Because of the way Voodoo emulation works, I run the game at a low res (640x480). You can go way higher, up to your native res, and the voodoo will scale beautifully, but the MFD integration with the cockpit when you zoom in glitches, breaking my carefully built immersion. I prefer the blur!