City of Heroes to Shut Down

Yes, but not from just normal drops. You need special Enhancement Unslotter salvage, which you can buy from merit reward vendors (should be on your map in most zones). I think you might randomly get some if you buy super packs on the auction house, too.

Or…when you respec, everything gets unslotted and you can reslot as you wish. Or just drop them into your inventory if you don’t want to slot them any more. With 70 inventory slots, that’s a lot of room to keep extraneous IOs. Of course, that means you have to go through the whole respec process.