I did the “guided” Nightfall and it went very smoothly. I was equipped at 280, my guides were 300 and 291, and we just played it straightforward and it went off without a hitch. No attempt to cheese anomalies needed, just advancing carefully but steadily, getting all the anomalies as we went. Got to the boss with about 12 minutes, eliminated him with just under five.
Downside: it took about 15–20 minutes queued waiting for some guides, but hey, that’s what picross on my iPad is for.