Out of the box, the picture modes are pretty good.
I’ve set up the below modes depending on what I’m doing:
ISF Bright: SDR video content
Game: SDR gaming
HDR Technicolor Expert: HDR video content
HDR Game: HDR gaming
Dolby Vision Cinema: Dolby Vision content
Mostly tuning my OLED light (only in SDR – leave the setting alone when using HDR or DV), turning Sharpness to zero, and turning off extraneous processing modes. The basics like Contrast, Brightness, Color, etc. are basically already set.