I’ve gotten this game to a set state I’m going to leave it in. I call it “Everything Is Beautiful, And Nothing Hurts”. Spoilers below.
The gang is at Horeshoe overlook. The gang is all together, Sean is rescued, we had our party. The key mission to really open things up is the story mission “Fisher Of Men” which is when you take little Jack fishing. This mission unlocks after both “Pouring Forth Oil” and the imfamous night out with Lenny. Once you have done this you can fish, hunt, and get the Legendary Fish map (you already have animals). The whole map is open, there are tons of stranger missions and sidequests open, like bounty hunting and all the find missions and challenges. You can gamble, take in a show, hunt, get in gunfights…
And as a bonus, Micah is in jail forever! Don’t go spring Micah, let him rot. Don’t collect that last fateful debt.
Now Arthur can live in peace and happiness, hunting and fishing and cowboying, never having gotten sick and with the camp and gang family happy and content.
I’ll stop with the story here, and pretend the bad times never happened. No regrets.