Current Best List:
Science
Skeptoid - This isn’t really a great news podcast (I guess Skeptics Guide to the Universe would be best for that), but it IS good if you like paranormal stories. Ten to Fifteen minutes weekly and he mostly avoids a lot of the ridiculous snippy asseded name calling that makes certain other skeptics (Rebeca Watson - I’m looking at you; though Evan can be a bit of a pill himself and they both contribute to make Skeptic’s Guide a little bit hard to sit through when they’re not just hitting the news) hard to stomach.
Television
IGN Channel Surfing - I hate the IGN games podcasts. Hate hate hate. I love this show. It’s full of real news from real people who really know real things (as opposed to rumors from random dumbasses who have too much time on their hands, which is the case for a surprising number of other television podcasts), and it’s good for getting an hour of information about stuff that I would generally be interested in every week or so. They tend to get a little irregular around the big press events (upfronts, Paley, some cons), but when they show up, they’re fantastic.
Comics
iFanboy - I hope hope hope that these guys manage to get Katers to start doing regular appearances, because that would be a murderer’s row of everybody that I like to hear from. I don’t even read most of the books they talk about - I just like hearing from these three guys on a regular basis, and it keeps me up to date on what’s going on in the comic book world.
Games
Idle Thumbs - I have ejaculated all over this podcast before, so I won’t bore you. Suffice it to say that they’re pretty good. GiantBomb is a little more rowdy and more regular if that’s your cup of tea.
Various Interests Not Including This American Life
The Moth Podcast - It’s a lot like This American Life, but only one person talking. Quality of the story varies from week to week with the speaker. The pitch is that it’s people telling real stories without a script in front of a live audience. Some of them have been pretty hilarious.
Comedy
SModcast - They have a network now which I intend to get a broader impression on, but Kevin Smith and Scott Mosier do a pretty great job of being funny about whatever they’re talking about when they’re not being preachy (they went through a period during the whole Too Fat for the Sky thing that strained my tolerance), which is almost all of the time. The guests are generally hilarious, and this is one of those few places where you’ll hear people talk about things that they don’t normally talk about. I feel like I learned more about what it’s like to be gay from Malcolm Ingram and Kev talking about his history in frank and gory detail than I have from any other source, ever.
Those are the biggest in the categories that I currently listen to. I’m planning on adding about ten more entries to the catcher soon, however, so we’ll see how that goes. There’s a lot more that I listen to intermittently, don’t listen to because I hate them, or haven’t included for some other reason if there’s a specific one that you’re looking for an opinion on.